Which substance is listed as increasing the risk of rhabdomyolysis?

• A. Statins
• B. Caffeine
• C. Creatine
• D. Aspirin

Answer: (A)

Statins can increase the risk of rhabdomyolysis because they may cause muscle cell injury in certain people, especially at higher doses or when used with other drugs or conditions that raise statin levels. When muscle cells break down, substances like CK and myoglobin enter the bloodstream; myoglobin can overwhelm the kidneys and lead to kidney injury in severe cases. In high‑intensity training or with dehydration, this risk is amplified for someone taking statins, which is why the association is strongest here.

Other substances listed are not typically linked to rhabdomyolysis on their own. Caffeine mainly acts as a stimulant and can contribute to dehydration in some contexts but isn’t a common cause of rhabdomyolysis. Creatine is generally considered safe for healthy individuals, and aspirin does not directly increase rhabdomyolysis risk.