Which organ pairing is listed as affected by metabolic disorders?

• A. Liver and pancreas
• B. Lungs and heart
• C. Skin and muscle
• D. Kidneys and adrenals

Answer: (A)

Metabolic disorders involve the processes that regulate energy use and storage in the body, so the organs that directly manage metabolism are most affected. The liver is a central metabolic hub: it stores glycogen, performs gluconeogenesis, and handles lipid metabolism and detoxification. The pancreas regulates blood glucose by producing insulin and glucagon, orchestrating how much glucose circulates and how it’s stored or used. Because these two organs are primary controllers of energy balance, they’re most commonly listed as affected by metabolic disorders.

Other pairings focus on systems not primarily responsible for metabolic regulation. Lungs and heart are mainly responsible for circulation and respiration, not direct metabolic processing. Skin and muscle can reflect metabolic issues but aren’t the core regulators. Kidneys and adrenals do play roles, but the liver and pancreas together best represent the central metabolic control points.