Where is leptin produced?

• A. Adipose tissue
• B. Liver
• C. Muscle
• D. Pancreas

Answer: (A)

Leptin is produced by adipose tissue, specifically by adipocytes in fat cells. The amount released into the bloodstream rises with total fat mass, so larger fat stores send a stronger leptin signal. Leptin then travels to the brain and binds receptors in the hypothalamus, where it helps regulate energy balance by reducing appetite and increasing energy expenditure. This makes it a long-term regulator of body weight, reflecting overall fat stores rather than quick changes. It’s not primarily produced by the liver, muscle, or pancreas, which have other hormonal roles. In obesity, high leptin levels can coincide with leptin resistance, diminishing the hormone’s ability to curb hunger despite ample fat stores.